Scientist, Downstream Development

This individual functions independently and productively as a Downstream Process Development scientist and is actively engaged in process and product development within a dynamic project team. Displays strong technical knowledge, initiative and scientific commitment, and makes significant scientific and technical contributions within Process Development Group.

Knowledge/Technical Expertise

Has considerable knowledge/expertise relevant to downstream processing of protein based products expressed in mammalian, bacterial, or yeast cells. Knowledge/expertise should be practical and focused on lab-related activities:

Downstream development of protein purification processes
Hands on experience with chromatography based processing methods and tangential flow filtration techniques
Experience with GE Healthcare’s AKTA line of chromatography systems is desired
Protein biochemistry (protein folding, protein degradation, aggregation, etc)
General analytical methods applicable for proteins (HPLC, electrophoresis, assay development, etc)
Knowledge of cGMP concepts
DOE as applied to process development/ optimization is desirable
Downstream technology transfer into cGMP manufacturing
Instrument care, maintenance, troubleshooting and data interpretation
Document writing, data interpretation, presentation, statistical analysis and trending.

Project Responsibilities

Implement knowledge/expertise to successfully execute specific aspect of a project:

Purification of specific protein molecule(s)
Purification methods development of specific protein molecule(s)
Development of downstream protein purification processes and technical transfer into cGMP
Preparation and authoring of technical reports
Interacting with appropriate analytical and upstream functional areas to determine appropriate method for protein purification
Participation in decision-making processes within the project team by actively engaging in scientific and technical discussions

Scientific & Technical Leadership

Builds credibility within lab group by performing high quality work.
Expands the technical capabilities of Process Development Group, such as technology development, use of the literature and systems development
Teaches others regarding their expertise, mentoring and training other members of Process Development Group as regards to day-to-day lab goals and activities.
Effectively communicates results of own work though scientific meetings, presentations, discussions and documentation with some input from supervisor.

Supervision

Minimum supervision required on day-to-day activities and accomplished tasks.
Supervisory input focused on status and future of project or technical area and long-term development path.
May have formal supervisory responsibilities, in which case the individual must create goals and development plans for direct reports, and be responsible for teaching, guiding, mentoring direct report(s).

Education and Previous Experience

Ph.D. degree (M.S. or B.S. with extended experience will be considered) in Chemistry, Biology, Life Sciences or related field, with 2-5 years of experience in pharmaceutical or biotechnology industry or academia.
A record of publications in internationally recognized journals is desirable.
The ability to work in team oriented environment is essential, as this person will work closely with other members of Process Development Group and participate on multidisciplinary project teams.

Primary candidates ONLY. No recruiting agencies.

Interested parties are encouraged to mail their CV with a cover letter to:

Paragon Bioservices, Inc.
Attn: Human Resources
801 W Baltimore St
Baltimore, MD 21201

lbutler@paragonbioservices.com