Upstream Development

  • Media formulation / optimization for microbial, baculoviral and mammalian cell culture projects.
    • Non-animal origin media solutions
    • Development of fed-batch strategies for higher cell densities and product titers
  • Optimization of expression kinetics
  • Optimization of product recovery
    • Centrifugation (including PK and AUC)
    • Tangential flow filtration (UF/MF)
    • Depth filtration
    • Inclusion body: solubilization, recovery and refolding optimization